Methylene Blue is a synthetic compound originally developed as a dye in the 19th century. As a medication, methylene blue was first used as an antimalarial treatment and was later approved to treat health conditions like methemoglobinemia. But over the years, scientists have discovered that methylene blue has some seriously impressive benefits for both the body and the brain, making it a potential game-changer. Some of the known benefits of methylene blue are: 

1. Improves Mitochondrial Function:
• Enhances energy production (ATP) in cells.
• Reduces harmful reactive oxygen species (ROS).
2. Protects and Treats Brain Conditions:
• Decreases harmful oxygen molecules.
• Protects brain cells in conditions like Alzheimer's, Parkinson's, and stroke.
3. Anti-Aging and Skin Health:
• Acts as an antioxidant.
• Boosts cellular energy, slowing down aging and maintaining healthier skin.
4. Effective Against Lyme Disease:
• Kills antibiotic-resistant bacteria causing Lyme disease.
5. Enhances Physical Performance:
• Increases ATP production.
• Reduces oxidative stress, improving muscle function and recovery.
6. Treats Depression:
• Lowers nitric oxide, stress, neuro-inflammation, and neurotoxicity.
• Shows significant improvement in severely depressed patients.
7. Antimicrobial Properties:
• Inhibits growth of bacteria and fungi.
• Helps prevent or reduce skin infections like staph.

And many more..

Various research articles and papers have been published to support these claims. Some of them are: 

1. Xue H, Thaivalappil A, Cao K. The Potentials of Methylene Blue as an Anti-Aging Drug. Cells. 2021 Dec 1;10(12):3379. doi: 10.3390/cells10123379. PMID: 34943887; PMCID: PMC8699482. {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699482/}
2. ⁠⁠Auchter A, Williams J, Barksdale B, Monfils MH, Gonzalez-Lima F. Therapeutic benefits of methylene blue on cognitive impairment during chronic cerebral hypoperfusion. J Alzheimers Dis. 2014;42 Suppl 4:S525-35. doi: 10.3233/JAD-141527. PMID: 25079810. {https://content.iospress.com/articles/journal-of-alzheimers-disease/jad141527}
3. Julio C. Rojas, Aleksandra K. Bruchey, F. Gonzalez-Lima. Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue, Progress in Neurobiology, Volume 96, Issue 1, 2012, Pages 32-45, ISSN 0301-0082, https://doi.org/10.1016/j.pneurobio.2011.10.007. {https://www.sciencedirect.com/science/article/abs/pii/S0301008211001948}
4. ⁠Vekaria HJ, Talley Watts L, Lin AL, Sullivan PG. Targeting mitochondrial dysfunction in CNS injury using Methylene Blue; still a magic bullet? Neurochem Int. 2017 Oct;109:117-125. doi: 10.1016/j.neuint.2017.04.004. Epub 2017 Apr 7. PMID: 28396091; PMCID: PMC5632129. {https://pubmed.ncbi.nlm.nih.gov/28396091/}
5. Naylor GJ, Smith AH, Connelly P. A controlled trial of methylene blue in severe depressive illness. Biol Psychiatry. 1987 May;22(5):657-9. doi: 10.1016/0006-3223(87)90194-6. PMID: 3555627. {https://pubmed.ncbi.nlm.nih.gov/3555627/}